Caffeine ally of the Immune System

Interleukin-17 (Th17)-producing T helper cells play a key role, promoting la formazione di una barriera protettiva nell’intestino e, in caso di infezione batterica o fungina, sono in grado di trasmettere segnali che favoriscono la risposta immunitaria. Il loro coinvolgimento, inoltre, è stato evidenziato anche in altri ambiti, come in corso di sclerosi multipla, artrite reumatoide, psoriasi.

By studying the cytokine cascade that leads to the development of Th17 cells, it was discovered that this cell population is able to proliferate even in the absence of intestinal microbiota or in subjects who had received antibiotics and therefore had a compromised intestinal microbiota. 

It has been discovered that intestinal epithelial cells under stress lead to differentiation of Th17 cells through purine metabolites, such as xanthine, an organic compound belonging to the group of purine bases, present in the form of caffeine in coffee, tea and chocolate, even in subjects without intestinal bacteria .

Paul Pellini

Profession Herbochemist
Consulting and Research Quality Control and Pharmacognostic and Cytotoxicological Evaluation of Plant Extracts of Medicinal Plants, Microalgae and Bud Derivatives and Microbiota Research of Medicinal Plants
Scientific Responsible: Center for Control and Scientific Dissemination of Natural Substances - CCDSN

Rome Italy

E-mail: paolo.pelini@gmail.com

http://www.paolopelinierbochimico.it

Academy.Edu

https://independent.academia.edu/PPelini

Received in the editorial staff on April 15, 2023