The survey, almost 3 out of 10 trials no disclosure 4 years from the end
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More transparency is needed in medical research and in particular in clinical trials: the results of tests on new drugs, vaccines and devices must be disclosed whatever their result, positive or negative.
And the recall launched by the World Health Organization, to encourage the sharing of scientific knowledge and promote the public health of all patients, ensuring that decisions on the safety and efficacy of innovative products are supported by the best available evidence.
The Geneva agency cites a survey that analyzed the results of large clinical trials registered on the clinicaltrials.gov website and completed by 2009: for 23% of the trials, no outcomes were reported after an average of 60 months from completion, for a total of nearly 300,000 patients involved.
And again: among the randomized clinical trials on vaccines against 5 diseases, registered between 2006 and 2012 in a variety of databases, only in 29% of cases the results were published in scientific journals within 24 months of completion, respecting the timeline recommended by WHO.
Finally, in another study that examined 400 randomly selected clinical trials, it was found that almost 30% of the studies 4 years after completion had not published the results, either in a scientific journal or in a clinical trial registry .
